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Papers of the Week

Papers: 29 Feb 2020 - 6 Mar 2020

Human Studies, Pharmacology/Drug Development

2020 Mar 02

JAMA Netw Open



Effect of Pregnenolone vs Placebo on Self-reported Chronic Low Back Pain Among US Military Veterans: A Randomized Clinical Trial.


Naylor JC, Kilts JD, Shampine LJ, Parke GJ, Wagner RH, Szabo ST, Smith KD, Allen TB, Telford-Marx EG, Dunn CE, Cuffe BT, O'Loughlin SH, Marx CE
JAMA Netw Open. 2020 Mar 02; 3(3):e200287.
PMID: 32119096.


In response to the national opioid public health crisis, there is an urgent need to develop nonopioid solutions for effective pain management. Neurosteroids are endogenous molecules with pleotropic actions that show promise for safe and effective treatment of chronic low back pain.