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Papers of the Week

Papers: 8 Feb 2020 - 14 Feb 2020

Human Studies

2020 07

Arthritis Rheumatol



Aberrant salience? Brain hyperactivation in response to pain onset and offset in fibromyalgia.


Hubbard CS, Lazaridou A, Cahalan CM, Kim J, Edwards RR, Napadow V, Loggia ML
Arthritis Rheumatol. 2020 07; 72(7):1203-1213.
PMID: 32017421.


While much brain research on fibromyalgia (FM) focuses on the study of hyper-responsiveness to painful stimuli, some studies suggest that the increased pain-related brain activity often reported in FM studies may be in part explained by stronger responses to salient aspects of the stimulation rather than, or in addition to, its painfulness. We thus hypothesized that FM patients would demonstrate elevated brain responses to both pain onset and offset, two salient sensory events of opposing valences.