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Papers of the Week

Papers: 1 Feb 2020 - 7 Feb 2020

Animal Studies, Pharmacology/Drug Development

2020 03 16

Neurosci Lett


Redox regulation of soluble epoxide hydroxylase does not affect pain behavior in mice.


Wack G, Eaton P, Schmidtko A, Kallenborn-Gerhardt W
Neurosci Lett. 2020 03 16; 721:134798.
PMID: 32006628.


Signaling mediated by soluble epoxide hydrolase (sEH) has been reported to play an important role in pain processing. Previous studies revealed that sEH activity is inhibited by specific binding of electrophiles to a redox-sensitive thiol (Cys521) adjacent to the catalytic center of the hydrolase. Here, we investigated if this redox-dependent modification of sEH is involved in pain processing using "redox-dead" knockin-mice (sEH-KI), in which the redox-sensitive cysteine is replaced by serine. However, behavioral characterization of sEH-KI mice in various animal models revealed that acute nociceptive, inflammatory, neuropathic, and visceral pain processing is not altered in sEH-KI mice. Thus, our results suggest that redox-dependent modifications of sEH are not critically involved in endogenous pain signaling in mice.