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Papers of the Week

Papers: 25 Jan 2020 - 31 Jan 2020

Animal Studies, Pharmacology/Drug Development

2020 04

Eur J Pain



Blockade of BDNF Signaling Attenuates Chronic Visceral Hypersensitivity in an IBS-like Rat Model.


Fan F, Tang Y, Dai H, Cao Y, Sun P, Chen Y, Chen A, Lin C
Eur J Pain. 2020 04; 24(4):839-850.
PMID: 31976585.


Irritable bowel syndrome (IBS) is a common functional disease characterized by chronic abdominal pain and changes in bowel movements. Effective therapy for visceral hypersensitivity in IBS patients remains challenging. This study investigated the roles of brain-derived neurotrophic factor (BDNF) and tyrosine kinase receptor B (TrkB) and the effect of ANA-12 (a selective antagonist of TrkB) on chronic visceral hypersensitivity in an IBS-like rat model.