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Papers of the Week

2020 Apr 10

Antioxid Redox Signal



Malabaricone C attenuates NSAID-induced gastric ulceration by reducing oxidative/nitrative stress and inflammation and promoting angiogenic auto-healing.


Maity B, Basak M, Mahata T, Chakraborti S, Kumar P, Bhattacharya B, Bandyopadhyay S K, Das M, Stewart A, Saha S
Antioxid Redox Signal. 2020 Apr 10; 32(11):766-784.
PMID: 31830804.


Non-steroidal anti-inflammatory drugs (NSAIDs), amongst the most commonly used drugs worldwide, are associated with gastrointestinal complications that severely limit the clinical utility of this essential class of pain medications. Here, we mechanistically dissect the protective impact of a natural product, malabaricone C, on NSAID-induced gastropathy.