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Papers of the Week

Papers: 23 Nov 2019 - 29 Nov 2019

Animal Studies

2020 Jul 09

J Crohns Colitis



Prescription opioid induce gut dysbiosis and exacerbate colitis in a murine model of Inflammatory Bowel Disease.


Sharma U, Olson R K, Erhart F N, Zhang L, Meng J, Segura B, Banerjee S, Sharma M, Saluja A K, Ramakrishnan S, Abreu MT, Roy S
J Crohns Colitis. 2020 Jul 09; 14(6):801-817.
PMID: 31773170.


Opioids are the most prescribed analgesics for pain in Inflammatory Bowel Diseases (IBD), however the consequences of opioid use on IBD severity is not well defined. This is the first study investigating consequences of hydromorphone in both dextran sodium sulfate (DSS)-induced colitis and spontaneous colitis [IL-10 knockout (IL-10-/-)] mouse model of IBD.