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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / Prescription opioid induce gut dysbiosis and exacerbate colitis in a murine model of Inflammatory Bowel Disease.

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Papers: 23 Nov 2019 - 29 Nov 2019


Animal Studies


2020 Jul 09


J Crohns Colitis


http://www.ncbi.nlm.nih.gov/pubmed/31773170?dopt=Abstract


14


6

Prescription opioid induce gut dysbiosis and exacerbate colitis in a murine model of Inflammatory Bowel Disease.

Authors

Prescription opioid induce gut dysbiosis and exacerbate colitis in a murine model of Inflammatory Bowel Disease.
Sharma U, Olson R K, Erhart F N, Zhang L, Meng J, Segura B, Banerjee S, Sharma M, Saluja A K, Ramakrishnan S, Abreu MT, Roy S
J Crohns Colitis. 2020 Jul 09; 14(6):801-817.
PMID: 31773170.

Abstract

Opioids are the most prescribed analgesics for pain in Inflammatory Bowel Diseases (IBD), however the consequences of opioid use on IBD severity is not well defined. This is the first study investigating consequences of hydromorphone in both dextran sodium sulfate (DSS)-induced colitis and spontaneous colitis [IL-10 knockout (IL-10-/-)] mouse model of IBD.
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