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Papers of the Week

Papers: 9 Nov 2019 - 15 Nov 2019

2019 Nov 12

Brain Sci



C-Fiber Assays in the Cornea vs. Skin.


Moulton EA, Borsook D
Brain Sci. 2019 Nov 12; 9(11).
PMID: 31718074.


C-fibers are unmyelinated nerve fibers that transmit high threshold mechanical, thermal, and chemical signals that are associated with pain sensations. This review examines current literature on measuring altered peripheral nerve morphology and discusses the most relevant aspects of corneal microscopy, especially whether corneal imaging presents significant method advantages over skin biopsy. Given its relative merits, corneal confocal microscopy would seem to be a more practical and patient-centric approach than utilizing skin biopsies.