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Papers of the Week

Papers: 9 Nov 2019 - 15 Nov 2019

Pharmacology/Drug Development

2020 Mar

Eur J Pain



The effects of long-term opioid treatment on the immune system in chronic non-cancer pain patients: A systematic review.


Diasso PDK, Birke H, Nielsen SD, Main KM, Højsted J, Sjøgren P, Kurita GP
Eur J Pain. 2020 Mar; 24(3):481-496.
PMID: 31705699.


Opioids have been increasingly prescribed for chronic non-cancer pain (CNCP). An association between long-term opioid treatment (L-TOT) of CNCP patients and suppression of both the innate and the adaptive immune system has been proposed. This systematic review aims at investigating the effects of L-TOT on the immune system in CNCP patients.