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Papers of the Week


Papers: 9 Nov 2019 - 15 Nov 2019


Pharmacology/Drug Development


2020 Mar


Eur J Pain


24


3

The effects of long-term opioid treatment on the immune system in chronic non-cancer pain patients: A systematic review.

Authors

Diasso PDK, Birke H, Nielsen SD, Main KM, Højsted J, Sjøgren P, Kurita GP
Eur J Pain. 2020 Mar; 24(3):481-496.
PMID: 31705699.

Abstract

Opioids have been increasingly prescribed for chronic non-cancer pain (CNCP). An association between long-term opioid treatment (L-TOT) of CNCP patients and suppression of both the innate and the adaptive immune system has been proposed. This systematic review aims at investigating the effects of L-TOT on the immune system in CNCP patients.