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Papers of the Week

2019 Nov 01

Life Sci


Inhibition of ovalbumin-induced allergic rhinitis by sumatriptan through the nitric oxide pathway in mice.


Hemmati S, Rahimi N, Dabiri S, Alaeddini M, Etemad-Moghadam S, Dehpour A R
Life Sci. 2019 Nov 01; 236:116901.
PMID: 31610206.


Allergic rhinitis is a global cause of disability, characterized by airway inflammation. Sumatriptan is a 5-hydroxytryptamine 1B/1D (5HT1B/1D) agonist used as a treatment for migraine headaches. Activation of 5HT1B/1D receptors can inhibit the release of neuropeptides and inhibit the inflammation cascades. This study investigated the effect of sumatriptan on ovalbumin-induced allergic rhinitis model in mice and the role of nitric oxide.