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Papers of the Week

2019 Nov 01

Life Sci


Intrathecally injected tramadol reduces articular incapacitation and edema in a rat model of lipopolysaccharide (LPS)-induced reactive arthritis.


Lucena F, Callado de Oliveira DMM, Norões MM, Mujica EMM, Melleu FF, de Benedet PO, Stein T, Ribeiro LFC, Tonussi CR
Life Sci. 2019 Nov 01; 236:116860.
PMID: 31518605.


Intrathecal injection of morphine presents analgesic and antiedematogenic effects in rats. However, it is unknown whether tramadol, which possess a mixed mechanism of action, can also produce analgesic and antiedematogenic effects similarly.