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Papers of the Week

Papers: 24 Aug 2019 - 30 Aug 2019

Animal Studies, Pharmacology/Drug Development

2020 Jan

Br J Pharmacol



The multifunctional peptide DN-9 produced peripherally acting antinociception in inflammatory and neuropathic pain via mu and kappa opioid receptors.


Xu B, Zhang M, Shi X, Zhang R, Chen D, Chen Y, Wang Z, Qiu Y, Zhang T, Xu K, Zhang X, Liedtke W, Wang R, Fang Q
Br J Pharmacol. 2020 Jan; 177(1):93-109.
PMID: 31444977.


Considerable effort has recently been directed at developing multifunctional opioid drugs to minimize the unwanted side-effects of opioid analgesics. We developed a novel multifunctional agonist named DN-9. Here, we studied the analgesic profiles and related side-effects of peripheral DN-9 in various pain models.