I am a
Home I AM A Search Login

Papers of the Week


Papers: 24 Aug 2019 - 30 Aug 2019


Animal Studies, Pharmacology/Drug Development


2020 Jan


Br J Pharmacol


177


1

The multifunctional peptide DN-9 produced peripherally acting antinociception in inflammatory and neuropathic pain via mu and kappa opioid receptors.

Authors

Xu B, Zhang M, Shi X, Zhang R, Chen D, Chen Y, Wang Z, Qiu Y, Zhang T, Xu K, Zhang X, Liedtke W, Wang R, Fang Q
Br J Pharmacol. 2020 Jan; 177(1):93-109.
PMID: 31444977.

Abstract

Considerable effort has recently been directed at developing multifunctional opioid drugs to minimize the unwanted side-effects of opioid analgesics. We developed a novel multifunctional agonist named DN-9. Here, we studied the analgesic profiles and related side-effects of peripheral DN-9 in various pain models.