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Papers of the Week

Papers: 10 Aug 2019 - 16 Aug 2019

Animal Studies, Human Studies

2019 Aug



Targeting nNOS ameliorates the severe neuropathic pain due to chronic pancreatitis.


Demir I E, Heinrich T, Carty DG, Saricaoglu Ö C, Klauss S, Teller S, Kehl T, Reyes C M, Tieftrunk E, Lazarou M, Bahceci DH, Gökcek B, Ucurum BE, Maak M, Diakopoulos KN, Lesina M, Schemann M, Erkan M, Krüger A, Algül H, et al.
EBioMedicine. 2019 Aug; 46:431-443.
PMID: 31401195.


Pain due to pancreatic cancer/PCa or chronic pancreatitis/CP, is notoriously resistant to the strongest pain medications. Here, we aimed at deciphering the specific molecular mediators of pain at surgical-stage pancreatic disease and to discover novel translational targets.