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Papers of the Week

Papers: 3 Aug 2019 - 9 Aug 2019

Pharmacology/Drug Development

2019 Aug 01

Reg Anesth Pain Med

Perioperative duloxetine for acute postoperative analgesia: a meta-analysis of randomized trials.


Zorrilla-Vaca A, Stone A, Caballero-Lozada A F, Paredes S, Grant M C
Reg Anesth Pain Med. 2019 Aug 01.
PMID: 31375539.


Multimodal analgesia is a fundamental part of modern surgery and enhanced recovery pathways. Duloxetine, a serotonin and norepinephrine reuptake inhibitor, has been validated for the treatment of chronic neuropathic pain. The evidence for duloxetine as an adjunct for the treatment of acute postoperative pain remains controversial. We conducted a meta-analysis to determine the efficacy of duloxetine in the acute perioperative setting.