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Papers of the Week

Papers: 13 Jul 2019 - 19 Jul 2019

Pharmacology/Drug Development


2019 Jun

Curr Opin Pharmacol


Sex differences in the pharmacology of itch therapies-a narrative review.


Schmid Y, Navarini A, Thomas Z-R M, Pfleiderer B, Krähenbühl S, Mueller SM
Curr Opin Pharmacol. 2019 Jun; 46:122-142.
PMID: 31299512.


Chronic itch is the most common skin-related condition, associated with a high psychosocial and economic burden. In recent years, increasing evidence of sex differences in the perception, clinical presentation and treatment requirements of itch points towards potential benefits when using sex-adapted therapies. It is well-known that body composition, absorption, metabolism, elimination and adverse drug reactions (ADRs) differ between sexes, but only little is known about the impact of sex in the pharmacology of itch treatments, which could help to rationalise sex-adapted treatment strategies.