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Papers of the Week


Papers: 13 Jul 2019 - 19 Jul 2019


Pharmacology/Drug Development

PAIN TYPE:
Itch


2019 Jun


Curr Opin Pharmacol


46

Sex differences in the pharmacology of itch therapies-a narrative review.

Authors

Schmid Y, Navarini A, Thomas Z-R M, Pfleiderer B, Krähenbühl S, Mueller SM
Curr Opin Pharmacol. 2019 Jun; 46:122-142.
PMID: 31299512.

Abstract

Chronic itch is the most common skin-related condition, associated with a high psychosocial and economic burden. In recent years, increasing evidence of sex differences in the perception, clinical presentation and treatment requirements of itch points towards potential benefits when using sex-adapted therapies. It is well-known that body composition, absorption, metabolism, elimination and adverse drug reactions (ADRs) differ between sexes, but only little is known about the impact of sex in the pharmacology of itch treatments, which could help to rationalise sex-adapted treatment strategies.