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Papers of the Week

Papers: 29 Jun 2019 - 5 Jul 2019

Human Studies, Pharmacology/Drug Development

2019 Oct

J Pain Symptom Manage



Minocycline for Symptom Reduction during Oxaliplatin-Based Chemotherapy for Colorectal Cancer: A Phase II Randomized Clinical Trial.


Wang X S, Shi Q, Bhadkamkar N, Cleeland CS, Garcia-Gonzalez A, Aguilar J, Heijnen C, Eng C
J Pain Symptom Manage. 2019 Oct; 58(4):662-671.
PMID: 31254639.


The most debilitating symptoms during oxaliplatin-based chemotherapy in patients with colorectal cancer (CRC) are neuropathy and fatigue. Inflammation has been suggested to contribute to these symptoms, and the anti-inflammatory agent minocycline is safe and readily available.