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Papers of the Week

Papers: 25 May 2019 - 31 May 2019

Animal Studies, Pharmacology/Drug Development

2019 Aug

Pharmacol Rep



Effect of TRPA1 activator allyl isothiocyanate (AITC) on rat dural and pial arteries.


Hansted A K, Bhatt D K, Olesen J, Jensen L J, Jansen-Olesen I
Pharmacol Rep. 2019 Aug; 71(4):565-572.
PMID: 31132686.


Transient receptor potential ankyrin 1 (TRPA1) channels may have a role in migraine as some substances known to cause headache activate the channel. In the craniovascular system such activation causes a calcitonin gene-related peptide (CGRP)-dependent increase in meningeal blood flow. TRPA1 channels in the endothelium of cerebral arteries cause vasodilation when activated. The headache preventive substance feverfew inhibits activation of TRPA1 channels. In this study we aim to compare and characterize the effect of the TRPA1 agonist allyl isothiocyanate (AITC) on the diameter of rat dural and pial arteries in vivo.