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Papers of the Week

Papers: 18 May 2019 - 24 May 2019

Human Studies, Pharmacology/Drug Development

2019 Sep

Eur J Pain



Effect of local infiltration with oxytocin on hemodynamic response to surgical incision and postoperative pain in patients having open laparoscopic surgery under general anesthesia.


Zayas-González H, Hernández A G, Manzano-García A, Hernández-Rivero D, García-Cuevas M A, Granados-Mortera J C, Vaca-Aguirre L, Flores-Fierro S, Condés-Lara M
Eur J Pain. 2019 Sep; 23(8):1519-1526.
PMID: 31116891.


Preemptive analgesia encompasses different perioperative interventions that have the final aim of decreasing postoperative pain and improving recovery. Recently, peripheral analgesic effects of oxytocinergic modulation have been suggested. In this regard, we tested the potential analgesic effects of subcutaneous oxytocin (OT) infiltration in patients submitted to laparoscopic cholecystectomy.