I am a
Home I AM A Search Login

Papers of the Week

Papers: 18 May 2019 - 24 May 2019

Animal Studies, Pharmacology/Drug Development

2019 May 21

J Neuroinflammation



Morphine immunomodulation prolongs inflammatory and postoperative pain while the novel analgesic ZH853 accelerates recovery and protects against latent sensitization.


Numerous studies have identified the proinflammatory, pronociceptive effects of morphine which ultimately exacerbate pain. Our novel endomorphin analog ZH853 does not produce proinflammatory effects on its own and gives potent, long-lasting analgesia. This study investigates whether ZH853's lack of interaction with the neuroimmune system reduces the risk of prolonged pain.