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Papers: 18 May 2019 - 24 May 2019
Animal Studies, Pharmacology/Drug Development
2019 May 21
J Neuroinflammation
16
1
Numerous studies have identified the proinflammatory, pronociceptive effects of morphine which ultimately exacerbate pain. Our novel endomorphin analog ZH853 does not produce proinflammatory effects on its own and gives potent, long-lasting analgesia. This study investigates whether ZH853's lack of interaction with the neuroimmune system reduces the risk of prolonged pain.