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Papers of the Week

2019 Aug 10

J Ethnopharmacol


Chemical profiling of secondary metabolites of Eugenia uniflora and their antioxidant, anti-inflammatory, pain killing and anti-diabetic activities: A comprehensive approach.


Sobeh M, El-Raey M, Rezq S, Abdelfattah MAO, Petruk G, Osman S, El-Shazly AM, El-Beshbishy HA, Mahmoud MF, Wink M
J Ethnopharmacol. 2019 Aug 10; 240:111939.
PMID: 31095981.


The red Brazilian cherry, Eugenia uniflora, is widely used in traditional medicine. The aim of this study was to investigate the phytochemical composition of a methanol extract from leaves of E. uniflora and characterization of the isolated compounds. In addition, we aimed to determine the antioxidant activities in vitro and in a cell-based (HaCaT cell) model. We also studied the anti-inflammatory, analgesic, antipyretic and antidiabetic activities in relevant rat models. The molecular mode of action of the antidiabetic activities was also investigated.