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Papers of the Week

Papers: 13 Apr 2019 - 19 Apr 2019

Pharmacology/Drug Development

2019 Jun

Clin J Pain



Opioid Pharmacology: Developmental Effects on Opioid Metabolism.


Kopecky EA
Clin J Pain. 2019 Jun; 35(6):481-486.
PMID: 30985400.


Children represent a patient demographic composed of multiple, unique subpopulations differentiated by rapidly changing age-related physiology, which includes the means of metabolizing opioids. Opioids are an important part of the pharmacological treatment of both acute and chronic pain. In both clinical medicine and clinical research, it is necessary to understand the differences in drug handling by age cohort in order to appropriately dose children to effect, and to avoid exacerbating deleterious adverse events with potentially grave sequelae.