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Papers of the Week

2019 Apr 12

Cochrane Database Syst Rev



Adjuvant therapy with antidepressants for the management of inflammatory bowel disease.


Mikocka-Walus A, Prady SL, Pollok J, Esterman AJ, Gordon AL, Knowles S, Andrews JM
Cochrane Database Syst Rev. 2019 Apr 12; 4(4):CD012680.
PMID: 30977111.


Symptoms of anxiety and depression are common in inflammatory bowel disease (IBD). Antidepressants are taken by approximately 30% of people with IBD. However, there are no current guidelines on treating co-morbid anxiety and depression in people with IBD with antidepressants, nor are there clear data on the role of antidepressants in managing physical symptoms of IBD.