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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / Transcriptional changes in response to ketamine ester-analogs SN 35210 and SN 35563 in the rat brain.

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Papers: 6 Apr 2019 - 12 Apr 2019


Animal Studies, Pharmacology/Drug Development


2019 Apr 11


BMC Genomics


http://www.ncbi.nlm.nih.gov/pubmed/30971208?dopt=Abstract


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Transcriptional changes in response to ketamine ester-analogs SN 35210 and SN 35563 in the rat brain.

Authors

Transcriptional changes in response to ketamine ester-analogs SN 35210 and SN 35563 in the rat brain.
Jacobson GM, Voss LJ, Klockars A, Bird S, Dimitrov I, Denny WA, Olszewski PK, Sleigh JW, Harvey MG
BMC Genomics. 2019 Apr 11; 20(1):281.
PMID: 30971208.

Abstract

Ketamine ester analogs, SN 35210 and SN 35563, demonstrate different pharmacological profiles to ketamine in animal models. Both confer hypnosis with predictably rapid offset yet, paradoxically, SN35563 induces a prolonged anti-nociceptive state. To explore underlying mechanisms, broad transcriptome changes were measured and compared across four relevant target regions of the rat brain.
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