I am a
Home I AM A Search Login

Papers of the Week

Papers: 6 Apr 2019 - 12 Apr 2019

Animal Studies, Pharmacology/Drug Development

2019 Apr 11

BMC Genomics



Transcriptional changes in response to ketamine ester-analogs SN 35210 and SN 35563 in the rat brain.


Jacobson GM, Voss LJ, Klockars A, Bird S, Dimitrov I, Denny WA, Olszewski PK, Sleigh JW, Harvey MG
BMC Genomics. 2019 Apr 11; 20(1):281.
PMID: 30971208.


Ketamine ester analogs, SN 35210 and SN 35563, demonstrate different pharmacological profiles to ketamine in animal models. Both confer hypnosis with predictably rapid offset yet, paradoxically, SN35563 induces a prolonged anti-nociceptive state. To explore underlying mechanisms, broad transcriptome changes were measured and compared across four relevant target regions of the rat brain.