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Papers: 6 Apr 2019 - 12 Apr 2019
Animal Studies, Pharmacology/Drug Development
2019 Apr 11
BMC Genomics
20
1
Ketamine ester analogs, SN 35210 and SN 35563, demonstrate different pharmacological profiles to ketamine in animal models. Both confer hypnosis with predictably rapid offset yet, paradoxically, SN35563 induces a prolonged anti-nociceptive state. To explore underlying mechanisms, broad transcriptome changes were measured and compared across four relevant target regions of the rat brain.