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- For Pain Patients and Professionals
2019 Mar 06
Neuron
101
5
Sodium channel Na1.7 is a major target in pain research, largely because of genetic validation. In this issue of Neuron, McDermott et al. (2019) now present a comprehensive assessment of congenital pain insensitivity due to Na1.7 loss of function. This work and studies on Na1.7 gain of function raise important questions about how channelopathies produce disease.