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Papers of the Week


Papers: 30 Mar 2019 - 5 Apr 2019


Animal Studies


2019 Mar 30


J Neuroinflammation


16


1

Hyperactivation of proprioceptors induces microglia-mediated long-lasting pain in a rat model of chronic fatigue syndrome.

Authors

Yasui M, Menjyo Y, Tokizane K, Shiozawa A, Tsuda M, Inoue K, Kiyama H
J Neuroinflammation. 2019 Mar 30; 16(1):67.
PMID: 30927920.

Abstract

Patients diagnosed with chronic fatigue syndrome (CFS) or fibromyalgia experience chronic pain. Concomitantly, the rat model of CFS exhibits microglial activation in the lumbar spinal cord and pain behavior without peripheral tissue damage and/or inflammation. The present study addressed the mechanism underlying the association between pain and chronic stress using this rat model.