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Papers of the Week

Papers: 30 Mar 2019 - 5 Apr 2019

Animal Studies

2019 Sep




Differential effect of FHM2 mutation on synaptic plasticity in distinct hippocampal regions.


de Iure A, Mazzocchetti P, Bastioli G, Picconi B, Costa C, Marchionni I, Casari G, Tozzi A, Pietrobon D, Calabresi P
Cephalalgia. 2019 Sep; 39(10):1333-1338.
PMID: 30922082.


Familial hemiplegic migraine 2 is a pathology linked to mutation of the ATP1A2 gene producing loss of function of the α2 Na/K-ATPase (NKA). W887R/+ knock-in (KI) mice are used to model the familial hemiplegic migraine 2 condition and are characterized by 50% reduced NKA expression in the brain and reduced rate of K and glutamate clearance by astrocytes. These alterations might, in turn, produce synaptic changes in synaptic transmission and plasticity. Memory and learning deficits observed in familial hemiplegic migraine patients could be ascribed to a possible alteration of hippocampal neuronal plasticity and measuring possible changes of long-term potentiation in familial hemiplegic migraine 2 KI mice might provide insights to strengthen this link.