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Papers of the Week

Papers: 16 Mar 2019 - 22 Mar 2019

Human Studies

2019 Mar 18

J Neuroinflammation



Expansion and activation of distinct central memory T lymphocyte subsets in complex regional pain syndrome.


Russo MA, Fiore NT, van Vreden C, Bailey D, Santarelli DM, McGuire HM, Fazekas de St Groth B, Austin PJ
J Neuroinflammation. 2019 Mar 18; 16(1):63.
PMID: 30885223.


Complex regional pain syndrome (CRPS) is a debilitating condition where trauma to a limb results in devastating persistent pain that is disproportionate to the initial injury. The pathophysiology of CRPS remains unknown; however, accumulating evidence suggests it is an immunoneurological disorder, especially in light of evidence of auto-antibodies in ~ 30% of patients. Despite this, a systematic assessment of all circulating leukocyte populations in CRPS has never been performed.