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Papers of the Week


Papers: 16 Mar 2019 - 22 Mar 2019


Human Studies

PAIN TYPE:
Migraine/Headache


2019


J Pain Res


12

APOLLO-1: a randomized placebo and active-controlled phase III study investigating oliceridine (TRV130), a G protein-biased ligand at the µ-opioid receptor, for management of moderate-to-severe acute pain following bunionectomy.

Abstract

Oliceridine is a novel G protein-biased µ-opioid receptor agonist designed to provide intravenous (IV) analgesia with a lower risk of opioid-related adverse events (ORAEs) than conventional opioids.