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Papers of the Week

Papers: 9 Mar 2019 - 15 Mar 2019

Human Studies, Pharmacology/Drug Development

2019 03 12




Association of Tramadol With All-Cause Mortality Among Patients With Osteoarthritis.


Zeng C, Dubreuil M, Larochelle MR, Lu N, Wei J, Choi HK, Lei G, Zhang Y
JAMA. 2019 03 12; 321(10):969-982.
PMID: 30860559.


An American Academy of Orthopaedic Surgeons guideline recommends tramadol for patients with knee osteoarthritis, and an American College of Rheumatology guideline conditionally recommends tramadol as first-line therapy for patients with knee osteoarthritis, along with nonsteroidal anti-inflammatory drugs.