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Papers of the Week

2019 Jun

J Pharm Pharmacol



Prolonged therapy with the anticonvulsant carbamazepine leads to increased plasma clearance of fentanyl.


Nozari A, Akeju O, Mirzakhani H, Eskandar E, Ma Z, Hossain M A, Wang Q, Greenblatt DJ, Martyn JJA
J Pharm Pharmacol. 2019 Jun; 71(6):982-987.
PMID: 30793320.


Fentanyl is a potent analgesic that accounts for an increasing number of overdose deaths in the United States. This study tested whether altered pharmacokinetics plays a pivotal role in the increased fentanyl dose requirements in patients receiving the enzyme-inducing anticonvulsant, carbamazepine.