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Papers of the Week
Prolonged therapy with the anticonvulsant carbamazepine leads to increased plasma clearance of fentanyl.
Abstract
Fentanyl is a potent analgesic that accounts for an increasing number of overdose deaths in the United States. This study tested whether altered pharmacokinetics plays a pivotal role in the increased fentanyl dose requirements in patients receiving the enzyme-inducing anticonvulsant, carbamazepine.