I am a
Home I AM A Search Login

Papers of the Week

2019 Apr

Mult Scler Relat Disord


Acylated and deacylated quillaja saponin-21 adjuvants have opposite roles when utilized for immunization of C57BL/6 mice model with MOG peptide.


Heidari A R, Boroumand-Noughabi S, Nosratabadi R, Lavi Arab F, Tabasi N, Rastin M, Mahmoudi M
Mult Scler Relat Disord. 2019 Apr; 29:68-82.
PMID: 30685444.


The majority of patients with multiple sclerosis (MS) suffer from central neuropathic pain (CNP). Using experimental autoimmune encephalomyelitis (EAE) model, only a few experiments were performed to assess pain behaviors in MS. To address this issue, complete Freund's adjuvant (CFA) was replaced with an acylated triterpene glycoside saponin adjuvant named quillaja saponin-21 (QS-21) to develop CNP in the EAE mouse model. The deacylated form of QS-21, named QT-0101, has been suggested to have an immunomodulatory effect. Thus, QT-0101 was used as a vaccine adjuvant to modulate the immune system against myelin oligodendrocyte glycoprotein (MOG35-55) antigen.