I am a
Home I AM A Search Login

Papers of the Week

Papers: 12 Jan 2019 - 18 Jan 2019

Animal Studies, Pharmacology/Drug Development

2019 Jan

Reg Anesth Pain Med



Efficacy of the ketamine metabolite (2R,6R)-hydroxynorketamine in mice models of pain.


Kroin JS, Das V, Moric M, Buvanendran A
Reg Anesth Pain Med. 2019 Jan; 44(1):111-117.
PMID: 30640662.


Ketamine has been shown to reduce chronic pain; however, the adverse events associated with ketamine makes it challenging for use outside of the perioperative setting. The ketamine metabolite (2R,6R)-hydroxynorketamine ((2R,6R)-HNK) has a therapeutic effect in mice models of depression, with minimal side effects. The objective of this study is to determine if (2R,6R)-HNK has efficacy in both acute and chronic mouse pain models.