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Little is known of how the presence of cranial autonomic symptoms (CAS) in cluster headache and migraine may contribute to their severe headache phenotype. However, this strong association points to […]
Learn More >Pain imposes a significant urden on patients, affecting them physically, psychologically, and economically. Despite numerous studies on the pathogenesis of pain, its clinical management remains suboptimal, leading to the under-treatment […]
Learn More >With concurrent global epidemics of chronic pain and opioid use disorders, there is a critical need to identify, target and manipulate specific cell populations expressing the mu-opioid receptor (MOR). However, […]
Learn More >Nanotechnology has been increasingly used in healthcare during recent years. However, the systematic evaluation of research on nanotechnology for pain management is lacking. In this study, we employed a bibliometric […]
Learn More >Pain and itch share similar neuronal networks; hence, it is difficult to explain why opioids can relieve pain but provoke itching. The present human volunteer study aimed to investigate the similarities […]
Learn More >Cell-specific alternative splicing of pre-mRNA generates functionally distinct voltage-gated Ca 2.2 channels. Ca 2.2 channels mediate the release of glutamate from nociceptor termini in the dorsal horn spinal cord and […]
Learn More >Real-world data on the effectiveness of systemic therapy in atopic dermatitis (AD) are limited.
Learn More >Opioid addiction is a chronic relapsing disorder in which drug-seeking behavior during abstinence can be provoked by exposure to a µ-opioid receptor (MOR) agonist or opioid-associated cues. Opioid self-administration behavior […]
Learn More >Chronic pain is the most common symptom for people who suffer from rheumatoid arthritis and it affects approximately 1% of the global population. Neuroinflammation in the spinal cord induces chronic […]
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NICE recommends rimegepant for treating acute migraine in adults.