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The Dopaminergic System In The Ventral Tegmental Area Contributes To Morphine Analgesia And Tolerance.

Morphine has a strong analgesic effect and is suitable for various types of pain, so it is widely used. But long-term usage of morphine can lead to drug tolerance, which […]

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Medium- and Long-Term Effects of Insomnia Severity and Circadian Preference on Pain and Emotional Distress Among Individuals with Chronic Pain.

Studies have identified insomnia as having significant influence on chronic pain. A rising body of research has also underscored the association between eveningness and chronic pain. However, co-assessment of insomnia […]

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Chronic pain and functional outcome 3 years after total knee arthroplasty and perioperative dexamethasone: a follow-up of the randomized, clinical DEX-2-TKA Trial.

Perioperative dexamethasone as an adjunct to multimodal analgesia, has an opioid-sparing and pain alleviating effect after total knee arthroplasty (TKA), however, the 3-year effects are unknown. We aimed to investigate […]

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Inflammation, lipids, and pain in vulvar disease.

Localized provoked vulvodynia (LPV) affects ~14 million people in the US (9% of women), destroying lives and relationships. LPV is characterized by chronic pain (> 3 months) upon touch to the […]

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Periodontal disease as a model to study chronic inflammation in aging.

Periodontal disease is a chronic inflammatory condition that results in the destruction of the teeth supporting tissues, eventually leading to the loss of teeth and reduced quality of life. In […]

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Fatigue in patients with newly diagnosed inflammatory bowel disease: Results from a prospective inception cohort, the IBSEN III study.

Although fatigue is common in inflammatory bowel disease (IBD), its pathogenesis remains unclear. This study aimed to determine the prevalence of fatigue and its associated factors in a cohort of […]

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The role of purity and frequency in the classification of perimenstrual headache.

Among all menstruation-associated headaches, only menstrual migraine has classification criteria in the International Classification of Headache Disorders 3rd edition (ICHD-3). Other menstruation-associated headaches are not generally described. The ICHD-3 classifies […]

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Long-term results of migraine surgery and the relationship between anatomical variations and pain.

Migraine headache surgery has been recently reported and supported by studies as management to provide long-term relief in migraine sufferers. This study aimed to monitor the long-term results of patients […]

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Virtual Reality for Chronic Pain Management Among Historically Marginalized Populations: Systematic Review of Usability Studies.

Virtual reality (VR) has potential to improve chronic pain management outcomes. However, the majority of studies assessing VR are conducted in predominantly White populations in well-resourced settings, thus leaving a […]

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Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection.

SARS-CoV-2 infection is associated with persistent, relapsing, or new symptoms or other health effects occurring after acute infection, termed postacute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID. […]

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