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To evaluate the long-term safety and tolerability of ubrogepant for the acute treatment of migraine.
Learn More >We investigated if parental multi-site chronic pain increases the risk of adult offspring developing additional chronic pain sites, and if offspring body mass index (BMI) and leisure time physical activity modify this association. We used longitudinal data on 7,654 offspring linked with their parents who participated in the population-based HUNT Study (Norway) in 1995-97 and 2006-08. Logistic regression was used to estimate odds ratios (ORs) with 95% confidence interval (CI). One-third of offspring (n=2,573) developed additional chronic pain sites. Having both parents with 1-2 chronic pain sites increased the risk of developing additional pain sites compared to having parents free of chronic pain (OR=1.33; 95% CI 1.05-1.68), with larger effects observed when both parents had ≥3 chronic pain sites (OR=1.46; 95% CI 1.17-1.82). These associations were largely driven by maternal pain, i.e., there was no association between paternal chronic pain and risk of additional pain sites in offspring. The parent-offspring transfer of additional pain sites (when both parents had ≥3 pain sites) strengthened when offspring were obese (OR=2.56; 95% CI 1.75-3.75) or physically inactive (OR=1.73; 95% CI 1.33-2.27). In conclusion, parental multi-site chronic pain increases the risk of offspring developing additional chronic pain sites, particularly those with obesity or inactivity. Perspective: This longitudinal analysis investigated the parent-offspring transmission of multi-site chronic pain, and whether lifestyle behaviours in offspring modify this association. The findings suggest that having parents with multi-site chronic pain increases the risk of offspring developing additional chronic pain sites, particularly if offspring are obese or inactive.
Learn More >To test the hypotheses that insufficient duration, high fragmentation, and poor sleep quality are temporally associated with migraine onset on the day immediately following the sleep period (day 0) and the following day (day 1).
Learn More >Patients suffering from fibromyalgia syndrome (FMS) are heterogenous. They often present with sensory abnormalities and comorbidities.
Learn More >Complex regional pain syndrome (CRPS) is a neuropathic pain condition of unknown etiology. Little is known of long-term outcomes of young adults who were diagnosed with CRPS as children.
Learn More >To investigate associations between experimental pain sensitivity and five chronic pain conditions among 655 participants in the OPPERA study.
Learn More >Fibromyalgia (FM) is a condition marked by widespread chronic pain and an array of somatic and psychological symptoms. The primary objective of this study was to explore daily associations between physical activity and pain intensity among a sample of women with FM and the potential moderation of this association by pain catastrophizing.
Learn More >Studies document that osteoarthritis-related joint pain is more severe in African American older adults, but research on the personal experience of osteoarthritis pain self-management in this population is limited. Using a qualitative descriptive design, our objective was to extend our understanding of the experience of life with osteoarthritis pain. Eighteen African Americans (50 years and older) were recruited from Louisiana to participate in a single semi-structured, in-depth interview. A conventional content analysis revealed that "Bearing the pain" characterized how older African Americans dealt with osteoarthritis. Bearing the pain comprised three actions: adjusting to pain, sharing pain with others, and trusting God as healer. We discovered that a metapersonal experience subsumes the complex biopsychosocial-cultural patterns and the intricate interaction of self, others, and God in living with and managing osteoarthritis pain. Study findings have implications for application of more inclusive self-management frameworks and interventions.
Learn More >The nucleus accumbens (NAc) has been implicated in sleep, reward, and pain modulation, but the relationship between these functional roles is unclear. This study aimed to determine if NAc function at the onset and offset of a noxious thermal stimulus is enhanced by rewarding music, and if that effect is reversed by experimental sleep disruption. Twenty-one healthy subjects underwent functional MRI (fMRI) scans on two separate days following both uninterrupted sleep and experimental sleep disruption. During fMRI scans, participants experienced noxious stimulation while listening to individualized rewarding or neutral music. Behavioral results revealed that rewarding music significantly reduced pain intensity compared to neutral music and disrupted sleep was associated with decreased pain intensity in the context of listening to music. In whole-brain FWE cluster-corrected analysis, NAc was activated at pain onset, but not during tonic pain or at pain offset. Sleep disruption attenuated NAc activation at pain onset and during tonic pain. Rewarding music altered NAc connectivity with key nodes of the corticostriatal circuits during pain onset. Sleep disruption increased reward-related connectivity between the NAc and the anterior midcingulate cortex (aMCC) at pain onset. This study thus indicates that experimental sleep disruption modulates NAc function during the onset of pain in a manner that may be conditional on the presence of competing reward-related stimuli. These findings point to potential mechanisms for the interaction between sleep, reward, and pain, and suggest that sleep disruption affects both the detection and processing of aversive stimuli that may have important implications for chronic pain.
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