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Predictive Model for the Non-Invasive Diagnosis of Endometriosis Based on Clinical Parameters.

Are other pain symptoms in addition to dysmenorrhea, dyspareunia, dyschezia, dysuria, and chronic pelvic pain correlated to endometriosis and suitable for a clinical prediction model?

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The Biology of Chronic Pain and Its Implications for Pain Neuroscience Education: State of the Art.

Pain is an individualized experience for the person suffering from chronic pain. Significant strides have been made in the last few decades in understanding various biological changes that coincide with […]

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Translation of Experimental Findings from Animal to Human Biology: Identification of Neuronal Mineralocorticoid and Glucocorticoid Receptors in a Sectioned Main Nerve Trunk of the Leg.

The activation of the mineralocorticoid (MR) and glucocorticoid (GR) receptors on peripheral sensory neurons seems to modify pain perception through both direct non-genomic and indirect genomic pathways. These distinct subpopulations […]

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Calcitonin Related Polypeptide Alpha Mediates Oral Cancer Pain.

Oral cancer patients suffer pain at the site of the cancer. Calcitonin gene related polypeptide (CGRP), a neuropeptide expressed by a subset of primary afferent neurons, promotes oral cancer growth. […]

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F-FDG and F-NaF PET/CT Global Assessment of Large Joint Inflammation and Bone Turnover in Rheumatoid Arthritis.

Rheumatoid arthritis (RA) involves chronic inflammation of synovial joints, causing pain, stiffness, and limited mobility. F-sodium fluoride (NaF) is a PET tracer whose uptake reflects bone turnover, while F-fludeoxyglucose (FDG) […]

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Persistent contralateral pain compromises exercise tolerance but does not alter corticomotor responses during repeated, submaximal isometric knee extensions to task failure.

Muscle pain is an important determinant of exercise tolerance, but its relationship with neurophysiological responses during a submaximal exercise trial is unclear. The purpose of this study was to determine […]

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The timing and magnitude of improvements in depression, anxiety, disability, and pain intensity during an internet-delivered program for chronic pain.

Numerous studies have found that pain management programs are an effective treatment option for people with chronic pain. However, little is known about when people experience improvements during these programs, […]

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Parkinson disease-related pains are not equal: clinical, somatosensory and cortical excitability findings in individuals with nociceptive pain.

Chronic pain is a frequent and burdensome non-motor symptom of Parkinson Disease (PD). PD-related chronic pain can be classified as nociceptive, neuropathic or nociplastic, the former being the most frequent […]

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The Natural History of Knee Osteoarthritis Pain Experience and Risk Profiles.

The study aimed to characterize the natural history of pain experience, concurrently considering intermittent and constant pain over 4 years and determine baseline factors associated with unfavorable trajectories in individuals […]

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Pain Catastrophizing: Controversies, Misconceptions and Future Directions.

Recent reports have pointed to problems with the term ‘pain catastrophizing’. Critiques of the term pain catastrophizing have come from several sources including individuals with chronic pain, advocates for individuals […]

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