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One of the advantages of CGRP monoclonal antibodies is their excellent safety and tolerability. However, postmarketing surveillance, is essential to detect potential rare emergent adverse events.
Learn More >A significant proportion of children/adolescents report Chronic Widespread Pain (CWP), but little is known about clinically relevant CWP or what factors lead to onset in this population. Objectives were to report the primary care consultation prevalence of CWP, and investigate risk factors associated with onset. A validated algorithm for identifying CWP status from primary care electronic healthcare records, was applied to a child/adolescent population (aged 8 to 18 years). The algorithm records patients who have recurrent pain consultations (axial skeleton and upper or lower limbs), or those with a non-specific generalised pain disorder (e.g. fibromyalgia). Prevalence was described, and a nested case-control study established to identify risk factors associated with CWP onset using logistic regression producing Odds Ratios (OR) and 95% Confidence Intervals (95%CI). 271 children/adolescents were identified with CWP, resulting in a five-year consultation prevalence of 3.19%. Risk factors significantly associated with CWP onset were; mental health (e.g. anxiety/neurosis consultations), neurological (e.g. headaches), genitourinary (e.g. cystitis), gastrointestinal (e.g. abdominal pain) and throat problems (e.g. sore throats). Children/adolescents with one or two risk factors (OR 2.15, 95% CI 1.6 to 2.9) or three or more risk factors (OR 9.17, 95% CI 5.9 to 14.3) were at significantly increased odds of CWP onset compared to those with none. Findings show a significant proportion of the child/adolescent primary care population have CWP. The majority of risk factors involved pain-related conditions, suggesting potential pathways of pain development. Further work is now needed to better understand the development of CWP in children and adolescents.
Learn More >Minimal clinically important difference (MCID) thresholds for a limited number of outcome metrics were previously defined for patients with failed back surgery syndrome (FBSS) at 6 months after spinal cord stimulation (SCS). This study aimed to further define MCID values for pain and disability outcomes. Additionally, the authors established 1-year MCID values for outcome measures with previously defined metrics commonly used to assess SCS efficacy.
Learn More >Cancer-related neuropathic pain (CNP) affects an increasing proportion of cancer patients given improved survival but remains difficult to treat. There are no studies on an extended intravenous (IV) ketamine protocol and its synergies with common neuropathy treatments to treat CNP. This study aims to (1) evaluate the safety and effectiveness of an IV ketamine protocol to treat refractory CNP and (2) uncover synergies between ketamine and common neuropathy treatments.
Learn More >Adolescent chronic pain exists within a social context, affecting the lives of adolescents, parents, peers, and wider family members. Typically, parental research has focussed on the negative impact on parents associated with parenting an adolescent with chronic pain. However, a small number of studies have identified positive parental outcomes and functioning, with a focus on parental resilience. This study sought to extend existing knowledge by providing a detailed and contextualized understanding of how parental dyads experience and demonstrate resilience in response to parenting an adolescent with Complex Regional Pain Syndrome (CRPS) and the meaning that parents ascribe to these shared experiences.
Learn More >Familial hemiplegic migraine (FHM) is an inherited autosomal dominant disorder characterized by migraine with reversible hemiplegia. FHM1 is caused by variants in CACNA1A, encoding a P/Q type neuronal voltage-gated calcium channel α subunit, which is also associated with episodic ataxia type 2 (EA2). FHM2 is associated with ATP1A2, which codes for an Na/K-ATPase isoform 2 subunit.
Learn More >There is a robust link between patients' expectations and clinical outcomes, as evidenced by the placebo effect. Expectations depend in large part on the context surrounding treatment, including the patient-provider interaction. Prior work indicates that providers' behavior and characteristics, including warmth and competence, can shape patient outcomes. Yet humans rapidly form trait impressions of others before any in-person interaction. It is unknown whether these first impressions influence subsequent health care choices and expectations.
Learn More >To evaluate whether the 15-day threshold of headache days per month adequately reflects substantial differences in disability across the full spectrum of migraine.
Learn More >To better characterize the ways that migraine affects multiple domains of life.
Learn More >Chronic pain is a common symptom experienced among patients with sickle cell disease (SCD). Our aims were to assess the feasibility and acceptability of performing acupuncture for the treatment of chronic pain in adults with SCD.
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