Rejected

Inflammatory pain occurs when local tissue injury activates macrophages and neutrophils, hence increasing pro-inflammatory cytokine and chemokine levels. Toll-like receptor 2 (TLR2) antagonism reportedly suppresses neuropathic and inflammatory pain.

The present study was designed as a prospective, randomized, double-blind clinical trial to evaluate the effects of preoperatively administered nefopam on postoperative acute hyperalgesia and the long-term painful sequelae compared to intraoperative administration.

Guillain-Barré syndrome (GBS) is an acute inflammatory demyelinating polyneuropathy that leads to sensory, motor and autonomic symptoms. We report a 26-year-old female patient with Guillain-Barré syndrome (GBS) revealed headache and limbs weakness. Treatment with gammaglobulin and corticosteroids led to a rapid improvement of musle strength. However, she developed more severe headache and increased intracranial pressure which can be relieved by ventricular drainage during recovery period of GBS. Headache and increased intracranial pressure in GBS was relatively rare. This report reviews some literatures about this disorder and analyses possible pathophysiological mechanisms of intracranial hypertension in GBS. We should pay attention to patients who exhibit atypical presentations.

To estimate the prevalence of chronic pain (CP) and high-impact chronic pain (HICP) in a sample of the general adult population in Saudi Arabia.

Achilles tendinopathy is a common overuse injury sustained by athletes (including runners) that often becomes chronic. There is evidence that chronic musculoskeletal pain conditions exhibit signs of nervous system sensitization.

Lasmiditan (REYVOW™; Eli Lilly and Company) is an orally available serotonin (5-HT) receptor agonist. In October 2019, the US FDA approved lasmiditan 50 mg and 100 mg tablets for the acute treatment of migraine with or without aura in adults. Approval was based on positive results from two pivotal phase III trials, in which lasmiditan significantly improved the proportions of patients achieving freedom from headache pain and freedom from the most bothersome symptom (photophobia, phonophobia or nausea), relative to placebo, when used to treat a migraine with moderate to severe pain. Lasmiditan is not for use in the preventive treatment of migraine. This article summarizes the milestones in the development of lasmiditan leading to its first approval for the acute treatment of migraine in adults.

Verapamil (VER) is a calcium channel blocker that is widely used to treat various cardiovascular diseases and is also effective in migraine prophylaxis. As the therapeutic range of VER is very narrow and toxicity can occur in patients after oral administration, therapeutic drug monitoring is recommended to optimize pharmacotherapy. The choice of an appropriate bioanalytical method for therapeutic drug monitoring of VER in the biological samples is a very important step in achieving fast and reliable results. This review focuses on the various analytical methods reported between 1976 and 2019 for the determination of VER in different biological samples and pharmaceutical dosage forms along with their methodological limitations. This review provides an overview for pharmaceutical industry researchers, clinicians and clinical chemists.

The National Institutes of Nursing Research provides funding via the P20 grant mechanism for research infrastructure and resources to develop nurse scientists with expertise in symptom self-management. The Medical University of South Carolina College of Nursing was awarded a P20 grant in 2016 to build the Symptoms Self-Management Center for technology-enhanced interventions to address pain and fatigue in individuals with chronic health conditions. Resources were derived from three key subcores: bioinformatics, mHealth and eHealth consultative services, and community engagement. This paper describes methods for deriving specific resources within each subcore, the application of subcore resources in two pilot studies, and lessons learned during the early phases of our Symptoms Self-Management Center implementation.

An oroantral fistula is by definition 'An abnormal communication between the oral cavity and the maxillary sinus.'