Rejected

Excessive daytime sleepiness in patients with obstructive sleep apnea is associated with substantial burden of illness.

Gout is the most common inflammatory arthritis affecting 1.1% of the population in mainland China with a higher prevalence in coastal areas.

Neuroleptic drug-induced parkinsonism (NIP) is a leading cause of parkinsonism, particularly in aging. Based on abnormal dopamine transporter scan results, individuals displaying chronic NIP are often diagnosed with Lewy-body Parkinson's disease (PD), but this assumption needs further substantiation.

School health has been considered as a high priority intervention in developing countries but it has not been prioritized in Nepal. The objectives of the study are to find out the prevalence of morbidity and nutritional status in school children.

The safety and pharmacokinetics of single and multiple doses of a novel mGlu receptor agonist prodrug, MGS0274 besylate (TS-134), were investigated in healthy subjects.

The aim of this study was to answer the following clinical question: "In patients admitted to a tertiary care hospital with a diagnosis of brain abscess, how common is odontogenic etiology?"

Hundreds of patients are treated for burn injuries each year at University of Wisconsin School of Medicine and Public Health. Pain management is particularly challenging during dressing changes and following skin grafting procedures. We performed a retrospective chart review from January 2011 through June 2018 to evaluate the effect of non-opioid analgesic medications on opioid use in non-intubated patients. Our primary outcome was the change in opioid use following the procedure. We found that most patients (69%) report severe pain (NRS ≥7) immediately after autologous skin grafting. On average, patients required an additional 52 mg of oral morphine equivalents (ME) in the 24 hours after the procedure compared to the 24 hours before. The use of perioperative non-opioid analgesia varied between patients (acetaminophen 29%, gabapentin 29%, ketamine 35% and all three 8%). Patients who received either gabapentin or a combination of acetaminophen, gabapentin and ketamine had a smaller increase in their opioid use than patients who did not receive the medications (-25 ME, 95% CI [-46, -4]; p=0.018 and -47 ME [-81, -11]; p=0.010 respectively). These results support using a combination of acetaminophen, gabapentin and ketamine for perioperative analgesia in burn patients undergoing autologous skin grafting.

Fibromyalgia syndrome (FMS), irritable bowel syndrome (IBS), and chronic fatigue syndrome (CFS) are traditionally considered as distinct entities grouped under chronic pain syndrome (CPS) of an unknown origin. However, these 3 disorders may exist on a spectrum with a shared pathophysiology.