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Chronic pain (CP) and thyroid hormones’ (TH) abnormalities are associated with depression, but the impact of pain and TH fluctuation on the response to depression treatment is uncertain.
Learn More >Vanilloids such as capsaicin and resiniferatoxin (RTX) are highly selective and potent activators for TRPV1, a nociceptor for heat and pain perception. However, the intrinsic vanilloid binding affinity, key for […]
Learn More >An objective measurement of chronic itch is necessary for improvements in patient care for numerous medical conditions. While wearables have shown promise for scratch detection, they are currently unable to […]
Learn More >In patients with neck pain, it is unclear whether pain inhibition and facilitation endogenous pain mechanisms are altered. This systematic review and meta-analysis aimed improve their understanding by assessing conditioned […]
Learn More >The efficiency of descending pain modulation, commonly assessed with the conditioned pain modulation (CPM) procedure, is diminished in patients with chronic pain. We hypothesized that the efficiency of pain modulation […]
Learn More >Chronic pain is a tremendous burden for afflicted individuals and society. Although opioids effectively relieve pain, significant adverse outcomes limit their utility and efficacy. To investigate alternate pain control mechanisms, […]
Learn More >Abdominal pain is highly prevalent in patients with inflammatory bowel disease (IBD) in remission, but the aetiology is incompletely understood.
Learn More >Continuous medical progress is significantly improving the quality of health care. As a result, people are living longer than during the past century, but this has also caused an increase […]
Learn More >This study is a secondary analysis evaluating changes in cognitive fusion and pain catastrophizing over 8 weeks of mindfulness-based cognitive therapy for migraine (MBCT-M) intervention versus waitlist/treatment as usual.
Learn More >GPR34 is a functional G-protein-coupled receptor of Lysophosphatidylserine (LysoPS), and has pathogenic roles in numerous diseases, yet remains poorly targeted. We herein report a cryo-electron microscopy (cryo-EM) structure of GPR34 […]
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