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Migraine: Advances in the Pathogenesis and Treatment.

This article presents a comprehensive review on migraine, a prevalent neurological disorder characterized by chronic headaches, by focusing on their pathogenesis and treatment advances. By examining molecular markers and leveraging […]

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Comparative retention and effectiveness of migraine preventive treatments: A nationwide registry-based cohort study.

Little is known about the comparative effects of migraine preventive drugs. We aimed to estimate treatment retention and effectiveness of migraine preventive drugs in a nationwide registry-based cohort study in […]

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Temperature-Sensitive Hydrogels as Carriers for Modulated Delivery of Acetaminophen.

The purposes of this study are the polymerization of temperature-sensitive copolymers based on N-isopropyl acrylamide and 10 mol % of 2-hydroxypropylmethacrylate, characterisations of their thermal, morphological and swelling properties, as […]

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“Buprenorphine, It Works so Differently”: Adults with Sickle Cell Disease Describe Transitioning to Buprenorphine for Treatment of Chronic Pain.

A growing body of literature describes the use of buprenorphine for the treatment of chronic pain in people with sickle cell disease. The experiences of people with sickle cell disease […]

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Thiostrepton alleviates experimental colitis by promoting RORγt ubiquitination and modulating dysbiosis.

Thiostrepton (TST) is a natural antibiotic with pleiotropic properties. This study aimed to elucidate the therapeutic effect of TST on experimental colitis and identify its targets. The effect of TST […]

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Soreness Reminds Me of Grief: Patients with Chronic Pain Show Less Differentiated Representations of Emotional Feelings and Bodily States.

People experience similarities between emotional feelings and bodily states on a daily basis, but both the magnitude and pervasiveness of this experiential similarity varies across individuals. Inspired by previous findings […]

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Large-scale momentary brain co-activation patterns are associated with hyperalgesia and mediate focal neurochemistry and cross-network functional connectivity in fibromyalgia.

Fibromyalgia has been characterized by augmented cross-network functional communication between the brain’s sensorimotor, default mode, and attentional (salience/ventral and dorsal) networks. However, the underlying mechanisms of these aberrant communication patterns […]

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Understanding, diagnosing, and treating Myalgic encephalomyelitis/chronic fatigue syndrome – State of the art: Report of the 2nd international meeting at the Charité fatigue center.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a devastating disease affecting millions of people worldwide. Due to the 2019 pandemic of coronavirus disease (COVID-19), we are facing a significant increase of […]

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UnCRMPing Nav1.7 to treat trigeminal neuropathic pain.

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ACCEPTANCE AND COMMITMENT THERAPY FOR CHRONIC PAIN: AN OVERVIEW OF SYSTEMATIC REVIEWS WITH META-ANALYSIS OF RANDOMIZED CLINICAL TRIALS.

This overview of reviews aimed to summarize the evidence from systematic reviews and meta-analysis of randomised clinical trials of the efficacy of Acceptance and Commitment Therapy (ACT) for adults with […]

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