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Age-dependent changes on fractalkine forms and their contribution to neurodegenerative diseases.

The chemokine fractalkine (FKN, CXCL1), a member of the CXC subfamily, contributes to neuron-glia interaction and the regulation of microglial cell activation. Fractalkine is expressed by neurons as a membrane-bound […]

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A progressive agenda toward equity in pain care.

There are inconsistencies documenting the pain experience of Black adults and other racially minoritized populations. Often disregarded, pain among these groups is characterized by misconceptions, biases, and discriminatory practices, which […]

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Ultrasound guided lavage with corticosteroid injection versus sham lavage with and without corticosteroid injection for calcific tendinopathy of shoulder: randomised double blinded multi-arm study.

To compare treatment effects between ultrasound guided lavage with corticosteroid injection and sham lavage with and without corticosteroid injection in patients with calcific tendinopathy of the shoulder.

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Editorial: Neurogenic inflammation in paroxysmal disorders (migraine and epilepsy).

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Continuous Fentanyl Administration and Spontaneous Withdrawal Decreases Home Cage Wheel Running in Rats with and without Hindpaw Inflammation.

Fentanyl is a potent analgesic with a rapid onset and short half-life that make it a useful treatment for pain and a lethal drug of abuse. The present study used […]

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Multimorbidity in people living with and beyond cancer: a scoping review.

Globally, both cancer incidence and survival are increasing. Early cancer detection and improved treatment means many people with cancer will survive for ten or more years following diagnosis. Multimorbidity, defined […]

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Association of Opioid Use Disorder Diagnosis with Use of Physical Therapy and Chiropractic Care among Chronic Low Back Pain Patients: A Group-Based Trajectory Analysis.

Nonpharmacologic approaches are recommended as first-line treatment for chronic pain and their importance is heightened among individuals with cooccurring opioid use disorder (OUD), in whom opioid therapies may be particularly […]

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Sex-specific adipose tissue’s dynamic role in metabolic and inflammatory response following peripheral nerve injury.

Epidemiological data and research highlight increased neuropathy and chronic pain prevalence among females, spanning metabolic and normometabolic contexts, including murine models. Prior findings demonstrated diverse immune and neuroimmune responses between […]

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Long-term Effects of Cannabidiol and/or Fentanyl Exposure in Rats Submitted to Neonatal Pain.

The current study aimed to evaluate anxiety behavior, hippocampal Iba1 and cannabinoid receptor type 1 (CB1) gene expression, and nociceptive response in adulthood after a combination of fentanyl and cannabidiol […]

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Structural studies of serotonin receptor family.

Serotonin receptors, also known as 5-HT receptors, belong to the G protein-coupled receptors (GPCRs) superfamily. They mediate the effects of serotonin, a neurotransmitter that plays a key role in a […]

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