Accepted

Current research reveals a complex relationship between blood cells(BC) and neuropathic pain(NP), though the underlying biological mechanisms remain unclear. This study applies Mendelian randomization (MR) to investigate causal relationships between […]

Knee osteoarthritis (KOA), predominantly affecting middle-aged and elderly populations, induces localized joint pain and functional impairment. It was to evaluate the effectiveness of acupotomy bone decompression (ABD) combined with sodium […]

Post-herpetic neuralgia (PHN) is a type of neuropathic (nerve) pain that persists for more than 3 months after crusting of the last shingles lesion. It is difficult to relieve with analgesic/adjuvant […]

Low back pain (LBP) is one of the main health problems imposing a significant burden both personally and socially. It is estimated that 70-85% of people experience LBP during their […]

Persistent pelvic pain is a prevalent condition that negatively impacts one’s physical, psychological, social, and sexual wellbeing. Pain science education (PSE) involves learning about the biology of pain and is […]

What is the comparative effectiveness and safety of commonly used interventional procedures (such as spinal injections and ablation procedures) for chronic axial and radicular spine pain that is not associated […]

Although μ-opioid receptor (MOR) agonists are the most effective drugs for relieving acute pain, nonselective activation of MOR can also lead to serious side effects. There is an urgent need […]

Neuropathic pain is triggered by nerve damage or disease and involves chronic neuroinflammation driven by activated microglia releasing pro-inflammatory cytokines. PANoptosis, a complex cell death program encompassing apoptosis, pyroptosis, and […]

Chronic pain affects a substantial portion of the population, yet current treatments often fail to provide adequate relief. Non-pharmacological interventions, which target behaviors and brain processes underlying the experience of […]