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Neuromodulation for primary headache disorders: Advantages and challenges.

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Secondary analysis: heat and self-report pain sensitivity associate with biological sex and racialized sociocultural group but may not be mediated by anxiety or pain catastrophizing.

Previous studies have demonstrated associations between sex and racialized group on pain sensitivity and tolerance. We analyzed the association of sex and racialized group on heat pain sensitivity, sensibility to […]

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Distinguishing fibromyalgia syndrome from small fiber neuropathy: a clinical guide.

Fibromyalgia syndrome (FMS) and small fiber neuropathy (SFN) are distinct pain conditions that share commonalities and may be challenging as for differential diagnosis.

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Sesame cake extract attenuates dextran sulfate sodium-induced colitis through inhibition of oxidative stress in mice.

Inflammatory bowel disease (IBD) is a chronic inflammatory disease occurring in the gut causing chronic diarrhea and abdominal pain with severe complications. Sesame cake is a by-product of sesame oil […]

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FOXD3-mediated transactivation of ALKBH5 promotes neuropathic pain via mA-dependent stabilization of 5-HT3A mRNA in sensory neurons.

The N6-methyladenosine (mA) modification of RNA is an emerging epigenetic regulatory mechanism that has been shown to participate in various pathophysiological processes. However, its involvement in modulating neuropathic pain is […]

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From the Gut to the Brain: The Role of Enteric Glial Cells and Their Involvement in the Pathogenesis of Parkinson’s Disease.

The brain-gut axis has been identified as an important contributor to the physiopathology of Parkinson’s disease. In this pathology, inflammation is thought to be driven by the damage caused by […]

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Virtual screening and molecular dynamics investigations using natural compounds against autotaxin for the treatment of chronic pain.

Chronic pain is a common and debilitating condition with a huge social and economic burden worldwide. Currently, available drugs in clinics are not adequately effective and possess a variety of […]

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12-(S)-Hydroxyeicosatetraenoic acid and GPR31 signaling in spinal cord in neuropathic pain.

Neuropathic pain is a pressing unmet medical need requiring novel non-opioid based therapeutic approaches. Using unbiased transcriptomic analysis, we found that the expression of , a G protein-coupled receptor, increased […]

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Disruption of mitochondrial pyruvate oxidation in dorsal root ganglia drives persistent nociceptive sensitization and causes pervasive transcriptomic alterations.

Metabolism is inextricably linked to every aspect of cellular function. In addition to energy production and biosynthesis, metabolism plays a crucial role in regulating signal transduction and gene expression. Altered […]

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Blocking brown adipocyte β-adrenoceptor attenuates blood-spinal cord barrier impairment and chronic postsurgical pain in a rat model of preoperative stress.

Preoperative stress has been recognized as an independent risk factor for chronic postsurgical pain (CPSP). However, the underlying mechanisms of CPSP influenced by preoperative stress remain elusive. Previous studies indicated […]

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