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The role of purinergic signaling in acupuncture-mediated relief of neuropathic and inflammatory pain.

Acupuncture is a traditional medicinal practice in China that has been increasingly recognized in other countries in recent decades. Notably, several reports have demonstrated that acupuncture can effectively aid in […]

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Deciphering the binding mechanism of gingerol molecules with plasma proteins: implications for drug delivery and therapeutic potential.

Ginger is a highly valued herb, renowned globally for its rich content of phenolic compounds. It has been traditionally used to treat various health conditions such as cardiovascular diseases, digestive […]

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Premonitory symptoms in migraine: A REFORM Study.

Estimates of proportions of people with migraine who report premonitory symptoms vary greatly among previous studies. Our aims were to establish the proportion of patients reporting premonitory symptoms and its […]

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Research trends and frontier hotspots of TRPV1 based on bibliometric and visualization analyses.

Transient receptor potential vanilloid type1 (TRPV1) is a non-selective cation channel with multiple activation mechanisms, which has received increasing attention since it was first cloned in 1997.

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Dorsal Root Ganglion Pulsed Neuromodulation Radiofrequency Treatment has Significant Clinical Efficacy in Chronic Spinal-origin Pain, Bringing Noticeable Improvement in Symptoms and Sleep Quality for Patients.

Chronic spinal-origin pain poses a substantial clinical challenge, prompting the investigation of novel treatment modalities. This study aims to evaluate the potential application of spinal nerve dorsal root ganglion radiofrequency […]

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Opioid-driven disruption of the septal complex reveals a role for neurotensin-expressing neurons in withdrawal.

Because opioid withdrawal is an intensely aversive experience, persons with opioid use disorder (OUD) often relapse to avoid it. The lateral septum (LS) is a forebrain structure that is important […]

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Screen time and pediatric headache: A scoping review of the literature.

The aim of this study was to summarize the evidence regarding screen use as a contributing factor in pediatric headache and migraine.

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Cbfβ regulates Wnt/β-catenin, Hippo/Yap, and TGFβ signaling pathways in articular cartilage homeostasis and protects from ACLT surgery-induced osteoarthritis.

As the most common degenerative joint disease, osteoarthritis (OA) contributes significantly to pain and disability during aging. Several genes of interest involved in articular cartilage damage in OA have been […]

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Changes in spinal motor behaviour are associated with reduction in disability in chronic low back pain: A longitudinal cohort study with 1-year follow-up.

The need to improve spinal motor behaviour in chronic low back pain (CLBP) rehabilitation remains unclear. The objective of this study was to test if changes in spinal motor behaviour […]

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Forced mouth opening induces post-traumatic hyperalgesia and associated peripheral sensitization after temporomandibular joints injury in mice.

Temporomandibular disorder (TMD) is the most prevalent painful condition in the craniofacial area. The pathophysiology of TMD is not fully understood, and it is necessary to understand pathophysiology underlying painful […]

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